Cholesterol managed PCSK9 drugs viewed by FDA

A popular commercial says that when diet and exercise isn’t enough to lower bad cholesterol levels, use “my brand”. It works for many people but there may be chronic side effects. New genetic research discusses possible genetic mutations along family and regional lines may be a factor for those who have difficulties maintaining ideal cholesterol levels, even with available cholesterol drugs. These mutations appear to alter the body’s natural way of creating and maintaining ideal cholesterol levels. Can cholesterol be managed by reducing a genetically high PCSK9 hormones? The European pharmaceutical markets seem to have found a possible solution. In the USA, these PCSK9 drugs are being viewed by FDA as a new route to controlling a prominent, serious problem.

It is estimated that about 75 million people in the USA have less than ideal cholesterol levels. Low density lipid (LDL) cholesterol levels aid in the possible clogging of key arteries leading to the heart or brain and are likely players for premature heart attacks and strokes. For many, diet and exercise can’t lower levels. Current drug classes are helpful but only somewhat effective and may have side-effects. Research shows that many people from particular regions have more cholesterol management problems and have isolated mutations in their genes. PCSK9 drugs is a class that targets those genes. After tests and marketing in Europe, the FDA is examining PCSK9 drugs from 3 companies. The genetic variant is from the D374Y gene, according to theory.

Stock analysts are carefully monitoring Amgen, Regeneron, and Sarnofi drug companies to determine which PCSK9 bad LDL cholesterol inhibitor will likely provide profitable gains. These drugs are a new class that are known as PCSK9 inhibitors that cardiologists find exciting in managing LDL in familial lines.

FDA reviewers endorsed Amgen’s drug evolocumab–to be sold as Repatha- as an effective therapy, tracking its ability to slash levels of bad cholesterol.

There are no long-term studies to demonstrate whether there are side-effects and PCSK9 inhibitors against a high-intensity statin studies have yet to be performed. Furthermore, the only major studies were sponsored from grants of the pharmaceutical manufacturers themselves.

Statin producers, such as Pfizer, Merck and Astra-Zeneca, have been performing tests in markets outside the USA, as high LDL levels are of worldwide significance. For these producers, these PCSK9 inhibitors can be supplements to current drug lines. The theory is that PCSK9 drugs target dangerously high cholesterol levels along family lines, regardless of diet, exercise, or even drug management.

The American Heart Association first brought up PCSK9 drugs as a viable weapon in 2010. Researchers at Harvard Medical School indicate PCSK9 drugs may be a formidable method to manage previously unmanageable LDL-class levels.

Your body makes cholesterol as an essential product each day. It is primarily produced by the liver. In those with ideal levels, there is no or little role of cholesterol plaque deposits that would cause athesclerosis, unless dietary cholesterol is abnormally high. PCSK9 has medical significance because it acts in cholesterol homeostasis, maintaining balance. The PCSK9 gene provides instructions for making a protein that helps regulate the amount of cholesterol in the bloodstream. Cholesterol is a waxy, fat-like substance that is produced in the body and obtained from foods that come from animals. Variants of PCSK9 can reduce or increase circulating cholesterol. PSCK9 drugs are designed to work at normalizing levels.

Mutations in the PCSK9 gene lead to an increase in the number of low-density lipoprotein receptors on the surface of liver cells. These mutations seem to be inherited along family tree links, theorists believe.

PCKK9 drugs are now administered by injections. They aren’t those easy pills you swallow with water. Another drawback is very high pricing. Express Scripts, a leading prescription insurance, plans to offer discounts to their subscribers.

PCSK9 drugs are one of the promising new theories aiming at bringing bad LDL back to ideal LDL levels in those with high levels. It has begun marketing in Europe, where the Amgen product has been a leader.

Statins, released in 1980, have been the most promising cholesterol management drug class. In prolonged use, some patients complained of peripheral circulation and muscular problems. A portion of those cite weakness as a side-effect. Muscular Dystrophy patients are strongly urged to avoid statin drugs. Statins are also found in nutritional substances, such as Red Yeast Rice – a popular cholesterol management supplement.

Certain plant sterols have been purported to have LDL cholesterol reduction abilities but may be similar to statins.

Financial investors are hoping PCSK9 drugs will elevate financial growth as the first major cholesterol management class in 35 years. People struggling with familial hypercholesterolemia are also hopeful.

Cholesterol is one of the many sterols produced by the body. The lethal consequences of imbalances in lipid and sterol metabolism in human diseases emphasize that any form of control may offer benefits with soft shadows of consequences. LDL cholesterol managed with PCSK9 drugs offer promising benefits and the marketers, investors, and medical community aren’t always responsible in expressing possible consequences. While the FDA is likely to approve release of PCSK9 drugs immediately, options must be considered.

Among the body’s structural benefits of cholesterol is particularly relevant in the central nervous system, where it represents one of the major components of myelin sheaths, and an important constituent of the synaptic vesicle membranes. Cholesterol helps maintain cell membranes health. Maintaining healthy levels of cholesterol at a proper homeostasis is valid when weighed against heart and brain problems. PCSK9 drugs present lots of possible benefits but, if there are imbalances, the long-term treatment may not be beneficial.

In any avenue of cholesterol management, responsible dieting and exercise are beneficial. There are no notions of sedentary lifestyles or body shapes with high serum LDL cholesterol levels. There have been observations along familial and regional lines, as well as income, according to the World Health Organization. Hereditary traits are often random and high LDL (in many) may be more nurture than nature. That they are natural and may lead to disease, use of PCSK9 drugs might be helpful to those who resist other forms of medicines and lifestyle choices.

In the United States, genetic testing is often rare and costly as compared to countries with nationally managed care. Whether a familial gene is at the core of your elevated cholesterol levels may be more of guesses than facts. While the producers of these costly PCSK9 drugs fund most tests for market popularity, those PCSK9 drugs might not be a wise choice for your doctor to recommend. Enthusiasm from Heart and Medical professional organizations may ultimately push PCSK9 drugs into the marketplace. Are they really for you?

The FDA claims PCSK9 drugs are still recommended as a treatment and not a cure. You might expect long-term, lifetime use. There are still more unbiased studies waiting to be performed, as well as real-life use to determine if PCSK9 drugs are what doctors and patients hope they will be. It often takes a decade to see if any drug, particularly genetic PCSK9 drugs, are really as good as they claim. For now, are you willing to be a test subject? Or should you just invest in a drug company’s stock or ETF?

Peter Pan Syndrome

Peter Pan is a tale of a boy that, despite many years passing, never grew up. The Peter Pan Syndrome (PPS) describes an adult man, who is childlike in their relationships, has about a 10-year old ability to handle responsibilities, and has a childlike pursuit of pleasure. Having Peter Pan Syndrome is not a disease. It’s a form of reality that has been hardwired as part of one’s personality. It can affect both men and women.

J.M. Barrie was a 19th-century Scottish dramatist, best known for writing Peter Pan or The Boy Who Would Never Grow Up, in 1904. This book is one of the most popular fantasies for children. The Peter Pan Syndrome is the dilemma of growing up when you really don’t want to. There really is no fix-all for this type of syndrome. In most cases it is hard-wired in neuron networks and there is nothing really that can change Peter Pan Syndrome from someone who does not agree.

You aren’t going to find this disease in a typical diagnostic psychology manual. It falls more in the pop-psychology genre. Peter Pan Syndrome was coined in a self-help book from 1983, The Peter Pan Syndrome: Men Who Have Never Grown Up. Author Dan Kiley may have had a Peter Pan fetish. The Chicago psychologist whose books “The Peter Pan Syndrome” and “The Wendy Dilemma” made The New York Times best-seller lists during the 1980s. Wendy was another character in the Peter Pan tale.

As sexual identities broaden and redefine, Peter Pan Syndrome might apply to adult men and women that never grew up. They are adults but their thoughts, actions, and motivations are pre-puberty. Those who might have Peter Pan Syndrome may have difficulty with creating intimate relationships or close friendships. They may have difficulty getting and holding jobs or pursuing careers.

In a demanding adult society, those with Peter Pan Syndrome may be anxious and fearsome of growing up to become “them” Depending on the degree, some Peter Pan type people may seem pretty normal and smart. Peter Pan was a hero, a leader, a fighter, and strategist. People with Peter Pan Syndrome are by no means stupid. They’re sort of socially and responsibly immature.

Peter Pan syndrome might be a personality disorder but. since it is not classified by the American Psychiatric or Psychological associations, it is not empirically studied or even diagnosed.

Puer-eternus is the predecessor to Peter Pan as the divine child that never grows up. Written about by Maria Louise von Franz of the Carl Jung school of analytical psychology, Puer-eternus applies to those men who, even though they’re in their 30’s, 40’s or 50’s have retained the emotional characteristics of an adolescent. Published in 1970, the origin could be found in Ovid Metamorphoses as attributed to a god of antiquity. Ovid speaks of the child-god named Iacchus.

Analysts believed Puer-Eternus (as a boy) had an inappropriately strong tie to the mother, positive or negative and a passive or negative father image. Prior to the acceptance of male homosexuality, analysts believed that homosexuality stemmed from this kind of a parenting relationship.

Today, Puer-Eternus or Peter Pan Syndrome seems to both apply to men and women that have never grown up. Those that may be affected by this syndrome are having difficulties in building relationships with others, thus, they can feel very lonely. Women may dress partly male and partly female of indeterminate gender appearance. Some theorists take a cognitive approach. Gender schema theory suggests that young children are influenced by society’s ideas about what it means to be a male or female in their culture. Peter Pan syndrome may be part of a rebellious notion toward androgyny – neither.

But, based on observations, these adults seem to fail to develop gender and social schemas beyond the age of 10 to 12, despite greater intellectual capacity. They are smart in many ways but lack emotional intelligence development for their older age.

As with 10 year olds, the adult is impulsive and impatient, has a low frustration tolerance, and a lack of patience, duty, endurance and difficulty accepting limitations imposed by others. Peter Pan can reason but only as a 10-year old might perceive what the world should be. While it’s good that a 10-year old offers spontaneity, potential creativity, childlike curiosity, the adult with Peter Pan Syndrome may eventually feel out of synch. The reasons will likely be diffused.

While anxieties and obsessions may arise, there are many pills that help control those symptoms. Alas, many with Peter Pan Syndrome accept this well integrated perception of living to be a problem. It doesn’t require magic dust. It is their reality. Contradiction is often a useless exercise.

A woman with Peter Pan Syndrome doesn’t think of marriage or intimacy. She might be called a Princess Pan. She aims for activity partners or casual friendships. They may be affectionate but not sexual. The female Peter Pan is usually the center of her universe, anxious about adventure and new concepts, and uncompromising. In relationships, other self-enforcing priorities supersede friendships. A Princess Pan is generally very self-centered, generally uncompromising, and probably uncommitted.

When it comes to jobs, those inclined to Peter Pan are less inclined to be able to work in ANY structured environment. They might be able to do something alone, provided that physical and social interaction are kept at a minimum.

At online dating sites, women grapple with Peter Pan Syndrome among men who don’t want to commit or behave intimately.

Apart from the benefits of immortality, normal life does pass. It’s no great thing to regret the past as you age. People with Peter Pan Syndrome may not reflect much on today and tomorrow. Perhaps, some day, they will reflect and regret those choices but, maybe, not.

Arguably, psychotherapy has been noted as possible treatment but motivation must be high. Someone with Peter Pan Syndrome must need intense motivation to grow up. That may be impossible. Children from birth develop temperaments and personality traits within a few years as the brain develops individuation. The establishment of these neural networks helps a person develop unique concepts of reality, likes and dislikes, tastes, attentions and responses to different things. One really can’t convince Peter Pan that there are benefits to growing up.

Peter Pan Syndrome is not retardation, autism, or stunted mental growth. Some of those that might have the syndrome may have achieved many high achievements and academic successes. They just sort of remain like kids. Being like a kid in an adult world of peers may be somewhat uncomfortable. Developing strong sexual and marital relationships might be impossible. People with Peter Pan Syndrome, like many kids, find it easier to find scapegoats for any problems they feel. Would Peter Pan ever accept blame for his own actions?

Since Peter Pan Syndrome isn’t accepted or recognized as a problem by accredited health care societies, there are next to none therapeutic interventions. One might call it a quirk. Pans may be likeable, attractive, and endearing on superficial levels with adults. On deeper levels, relationships tend to weaken. There are many Pans and, eventually, they will find their Tiger Lily or Tiger Larry as a supportive, submissive partner. As long as they have the basics of food, clothing, shelter, and entertainment, people with Peter Pan Syndrome are easily satisfied.

With little data to further examine people with Peter Pan Syndrome (other than anecdotal references), there are few suppositions and tools to help someone you know or someone in your family cope with never growing old. Peter Pan Syndrome is a complex that may affect men and women. They won’t believe you. They’ll brush you off as being “Daffy”. After repetitive attempts, you will be as tense as Captain Hook thinking about that ticking alligator. Should Peter Pan Syndrome receive more attention by the scientific community?

Standing is healthier to fight sedentary lifestyle?

Is your workplace killing you? It’s a possibility. At 8-hours per day, work covers one-third of your life. It contributes to a sedentary lifestyle that is further enhanced at home. Thoughts are rising about how a sedentary lifestyle may be hazardous to your health. Dong something about it is easier said than done. Yet, each day you wait may result in some toxicity that is avoidable. Is standing healthier to fight a sedentary lifestyle? Are you ready to explore this further? The answers may surprise you.

It doesn’t take a lot of sense to figure out that there are several health implications due to more sedentary lifestyles. New studies are demonstrating how lower activity levels impact physiological activity in your body.

Physiology aims to understand the mechanisms of living – how living things work. Human physiology studies how our cells, muscles and organs work together, and how they interact. Changes and greater access to different modes of transportation and mechanics over the past 500 years may have affected human physiological systems. Some say they constitute the basis of new motion diseases and pains over the past few decades.

20th and 21st century technology improvements have radically changed lifestyle choices. More people rely on vehicular transportation than walking. People sit while listening to radio, watch TV, and “work” at their computer. Thankfully, mobile technology is helping take radio, TV, and computing features here and there but more people continue to sit. On the positive side, hand muscles may develop as more people text than speak on those mobile devices.

One recent study of young people, age 2 to 18 and their sedentary ways. Observations that the tested people spend 2–4 hours per day in screen-based behaviors and 5–10 hours per day sedentary. Some say that parents use TV as a form of babysitting. According to an article published by the American Association of Pediatrics, use of tablets is increasing among 6-month to 4-year age groups, sacrificing some other motion-related activities.

A relationship between sedentary behaviour and deleterious health consequences was noted as early as the 17th century by occupational physician Bernadino Ramazzini. Ramazzini catalogued how activity can change the make-up of nerves and muscles and the onsets of certain diseases. He is regarded as the father of occupational medicine by many.

Occupational medicine has become a multidisciplinary approach in the prevention, diagnosis and treatment of workplace injuries and illnesses. Researchers in this field offered significant research in keyboard designs and the prevention of repetitive motion diseases affecting hands and forearms. Occupational medicine has explored and developed ergonomic approaches to prevent such diseases in offices and other work places. Some of those ergonomic approaches and recommendations are often not adopted by work areas or easily adapted by individuals.

The ramifications, however, are spreading wider beyond the scope of merely workplaces. Harvard researchers found in a recent February study involving more than 92,000 women that the more time participants spent sitting at work, driving, or watching TV, the greater their risk of dying from heart disease, cancer, or strokes. Basically, “too much sitting can lead to death” so excessive sedentary behaviors may be as threatening as smoking. It can also be addictive. Some believe that sedentarianism is an addictive disorder.

Many workplaces, where people spend approximately one-third of their lives, seemed interested in using work stands over traditional desks. One company, HubSpot, an inbound marketing and sales software company, purchased sit/stand desks that raise and lower with the push of a button for all 650 employees this year after staffers started asking for them. This simplistic and costly suggestion and implementation did not work as thought. Standing may burn more calories than sitting as hearts work harder to circulate blood upward. Standing also puts more strain on our veins, backs, and joints, especially if we’re overweight. This is why more chairs were introduced in workplaces over 100 years ago. Remember Bob Cratchett’s high desk in the Christmas Carol?

Prolonged standing causes health problems too. Plenty of studies show that it may significantly increase the risk of carotid atherosclerosis (a disease of the arteries in your neck) due to the extra load on your circulatory system to move blood to your brain. This may translate to the possibility of a stroke.

A study on economic costs of pain discussed that over 100 million people in the United States suffer from chronic pain from muscles and joints. The study found that the annual costs of pain were higher than the 2010 expenditures of heart disease, cancer, and diabetes.

Finding sources of pain and treatments might be beyond most Americans through lack of adequate insurance and knowledge. Highly technological diagnostic tests may be used to pinpoint possible sources. Where there is no specific cause, doctors may provide a diagnosis of fibromyalgia or rheumatism. Fibromyalgia syndrome is a common and chronic muscular disorder characterized by widespread pain, diffuse tenderness, and a number of other symptoms. Rheumatism is often associated with arthritis but a more debilitating form. Both might be associated with sedentary lifestyles but may also result from accidents and other things. The problem is that both fibromyalgia and rheumatism are blanket terms that may consist of hundreds (if not thousands) of possible causes.

Apart from steroid and non-steroid analgesics, acupuncture, or Reiki, physical therapy is most often prescribed as a possible bridge to pain relief. Physical therapy is often called medical exercise and is used for a wide scope of pain and mobility disorders. The efficacy of physical therapy has been questioned and proven as beneficial to some, long-term patient compliance tends to drop dramatically after a few sessions.

Chiropractors often discuss that gravity is a constant stressor to possible back pain and certain postural conditions that are pain associated.

More research is being focused on the effects of sedentary behaviors. If chronic pains and sedentariness prove more positive, exercise therapy may prove positive. Of course, 30 minutes of exercise daily may not reverse the possible negatives of chronically sedentary conditions, it is better than zero. Overall, physical activity lifestyle changes have been examined and recommended as probable mediators that may reduce the effects of many hours and years of being mostly sedentary.

Age, gravity, furniture, and other variables may, through your lifetime, result in agony. You could sit through it or start moving – even walking habitually at a brisk pace for a longer time span each day. It’s easier to say and listen than doing.

It is likely that most healthcare providers will recommend activity and physical therapy. Do your homework. It is strongly advisable to undergo a thorough medical examination prior to beginning a physical activity regimen. Sedentary behaviors may be life threatening but activity may be shocking to your body’s age-old balancing systems called homeostasis or survival through stability. Finding a balance between sedentary and active has been established to help support longer living and less pain.

Pain management specialists are licensed medical doctors that deal with people who have difficulties or pain associated with moving. Clinical research is continually being conducted to help determine which pain management therapies are the most effective in treating back pain and neck pain. There are various diagnostic paths to find the sources that might be ailing you. Pain management specialists are most commonly found in the following disciplines:

•Physiatry (also called Physical medicine and rehabilitation) – MD
•Anesthesiology – MD
•Interventional radiology – MD
•Physical therapy (usually Ph.D.)

The most important consideration in looking for a pain management specialist is to find someone who has the training and experience to help you with your particular pain problem. You must also find one who is willing to interact with you in positive, productive ways. Generally, other pain specialists and therapists may be involved in the course of your treatment. Guess what? Most will be anti-sedentary. That is why you need to create a cooperative relationship with the pain-management specialist who is monitoring your course of treatment. If sedentary lifestyle behaviors are at the root of your problem, they can help (if you feel positive).

One form of activity you can do at your desk is Progressive Exercise and one of the promoters is a company that produces products many professional physical therapists use. Progressive resistance exercise (PRE) is a method of increasing the ability of muscles to generate force. TheraBand is a selection of large rubber bands (generally 3 to 5 feet long each), with varying resistance gradients classed by color. There are groups of exercises that you can do at your desk or on your couch. These devices are available by many online and fitness stores. If you are in a physical therapy treatment, it may be advisable to speak with your therapist about this about whether this might apply to your condition.

Altering your current everyday tasks to increase your physical activity, may be painful if irresponsible. Sitting and moving require attention and perseverance. The acts of movement integration to your living lifestyle require patience and positive attitudes. Are you ready?