Benefits and consequences of COVID-19 vaccine

The COVID-19 vaccine is coming. But is it ready to be used?

There’s a great deal of optimism as Pfizer begins deliveries of their vaccine to USA. There are, however, some that believe there’s a bumpy road ahead about results and side-effects. They prefer to wait. How efficient is this vaccine? Does it cover only D614b (original form)? Does it cover all COVID-19 mutations?

The first people to be vaccinated are the guinea pigs of what may be a vast, ghastly experiment.

COVID-19 vaccine production spans only less than 1 year for testing, far less than average for many drugs. They may stop the world’s tragic COVID-19 pandemic but those benefits come with a barrel of consequential side-effects that may be worse to several people:

Shortness of breath.
Joint pain.
Muscle pain
Fast or pounding heartbeat
Loss of smell or taste
Memory, concentration or sleep problems
Rash or hair loss

According to CNBC, the FDA said that while side effects of the Pfizer vaccine are common, there are “no specific safety concerns identified that would preclude issuance of an EUA.” CNBC continues, the information shows it has benefits even after the first dose, with an effectiveness of more than 50 percent about a week later. Shots are given 3-weeks apart.

Does your health insurance cover that significant 2nd shot? It may or may not. You really need to contact carriers for written approval.

Among other issues, UK has observed allergic reactions that may have been caused by a component of Pfizer’s vaccine called polyethylene glycol, or PEG, which helps stabilize the shot and is not in other types of vaccines.

There are also more types of COVID-19 than 12 months ago. Researchers call the new strain G614 and the previous strain D614. One of the researchers who worked on the study told CNN that the new mutation is “now the dominant form infecting people.”

According to Medical News Today, ll viruses mutate, and the new coronavirus, SARS-CoV-2, is no exception. As an RNA virus, it is prone to mutations, partly because the replication enzymes of RNA viruses make more mistakes when copying genetic material from cells that it settles on. The G614 variant first piqued a study team’s (at Los Alamos Labs interest in April, when they noticed a repeated pattern across the globe.

An assumption that the D614 strain has a mean generation time of ~5 days, researchers calculated that the G614 strain has a reproduction number 31% times higher than the D614 strain. The estimate above is based on the number of confirmed cases, but if deaths are used instead, the result would be a 23% higher reproduction number.

The new strain of coronavirus, called D614G (G614), emerged in Europe and has become the most common in the world. Research at the University of North Carolina at Chapel Hill and the University of Wisconsin-Madison shows the D614G strain replicates faster and is more transmissible than the virus, originating in China, that spread in the beginning of the pandemic.D614G is responsible for increasing spikes throughout the globe.

According to Bio-Pharma, a group of Australian scientists believe that effectiveness of D614 vaccines should also be effective with G614 mutations. The report was in October 2020, so it’s more theoretical.

The pandemic is serious by deaths, social isolation, and economic upheaval. Welcoming the Pfizer vaccine is the first glimmer of hope in this trying year. We’ve no idea of the incidence of side-effects and the duration of drug efficacy. Who knows? An H614 may be developing but we don’t know about it yet. I think better research is required.