Britain debates 3-parent babies and mitochondria

When we talk about nature and nurture in child rearing, nature meant mom and dad’s genes. What happens when a third party is introduced? That is what Britain is beginning to debate. It can stir a lot of feelings about traditional and progressive marriages. New concepts and biological research seem to point to mitochondria cellular components that help bring energy to different cells.

The long hope of British scientists is to help eliminate mitochondrial diseases that can result in nerve, brain, muscle, and organ diseases. The debate rides on many traditional and progressive issues. Based on theories and research, testing the effect of using a 3-parent baby with an extra sample of mitochondria may take generations to foresee a reasonable outcome. Then again, can science be inadvertently producing a class of monsters?

The British aren’t the only ones targeting mitochondria alterations at a genetic level. The United States Food and Drug Administration or FDA is pondering implications. The scope of questons include how genes are transmitted through subsequent generations.

As one of the countries offering nationwide health insurance, Britain’s stake is more than bottom-line economics. People with mitochondrial diseases are significant burdens to the nation’s insurance budget. Finding a way to reduce incidences is a good long-term investment for Britain, beyond moral indignation.

USA has no such program. Funding can be an economic disaster. With about 100 years as a gap for successful return, it is a risky long-term investment. There’s more study needed on mitochondria and how, when and why they mutate. As a business, can quality control be assured? How will research and clinical evaluations be studied with no or limited insurance policies? Is it profitable? Many US businesses that championed progress in the 1900’s are no longer around. Can USA rely that current champions will be around to see the results of 3-baby parenting?

The scientific goal is a noble one. Three-parent babies are human offspring with three genetic parents, created through a specialized form of in-vitro fertilization The future baby’s mitochondrial DNA comes from a third party. The procedure is intended to prevent mitochondrial diseases including muscular dystrophy and some heart and liver conditions that currently disable offspring with disabling conditions.

Essentially, nurture is a 2-parent baby. Nature is still 2 parents but with sperm from a “healthy” donor. You don’t have to change your bedroom furniture. The 3-parent baby is a choice of several options. At its early stage, it’s exciting and bringing mitochondria into the forefront as a means of fighting or preventing mitochondrial diseases.

Mitochondria are important aspects of a cell that theoretically account for 90% of the energy required to sustain cellular health. What can happen when the mitochondria fail? Diseases of the mitochondria appear to cause the most damage to cells of the brain, heart, liver, skeletal muscles, kidney and the endocrine and respiratory systems. Mitochondria are associated as powerhouses of genetic material within cells. They help provide energy to your entire body. It’s simple but, at the same time, mitochondrial disease can effect all of use to certain degrees.

Conventional biology instruction associates mitochondria at cellular levels but recent research cite evidence that it is oversimplified. It takes about 3000 genes to make a mitochondrion. Mitochondrial DNA encodes just 37 of these genes.Mitochondrial diseases are the result of either inherited or spontaneous mutations within different aspects of DNA which lead to altered functions of the proteins or RNA molecules that normally reside in mitochondria. Mitochondria are also associated for cholesterol metabolism, for estrogen and testosterone synthesis, for neurotransmitter metabolism, and for free radical production and detoxification. Cellular roles in transmitting genetic diseases seem a little more complicated than a crap shoot. In the human condition, diet and health management may be fighting the norms of your cells.

The North American Mitochondrial Disease Consortium or NAMDC is one of several research institutes that study the many roles that mitochondria play behind disabling diseases that can span lifetimes. Over a couple years, Britain scientists have been developing research and techniques to produce the first 3-parent babies as a revolution betting on healthier outcomes. As with all revolutions and research results, it is a role of dice type of gambling.

The stakes are high. Responsible parents often debate about having children when development or neuro and muscular diseases are in their lineage. Birthing babies with autism, muscular dystrophy, and others pose incredible stress to parents and growing children as they attempt to cope with disabilities in a very able world.

Equally disruptive is that some of these mitochondrial glitches may remain dormant through a life-span and attack adults at many ages. This can be equally shocking and often misdiagnosed by medical specialists. Many of these mitochondrial myopathies introduce vast symptoms that take normal people into tunnels of greater challenges, with no available cure.

The gamble of theories that challenge traditional thought of the etiologies of many diseases may actually be results of this gelatinous material that resides in each and every human cell.

For those suffering with neuropathies, myopathies, and countless other diseases that may benefit from 3-parent baby research, the results are of a very long range. We are counting on better statistics from future generations. Further mitochondrial research may result with better treatments for current diseases but is more hope than fact.

Faiths who have lost political struggles with homosexual marriages might see 3-parent babies as further affronts to religious traditions. The thought of a 3-parent baby does seem puzzling in battling something that causes mitochondrial disease. There are choices of pre-natal testing to discover whether your baby has mitochondrial disease. At that point, you might choose to abort the child. The Right to Life movement hotly debates this choice. For all god’s miracles, there are the victims.

Yet…if 3-parent baby research can play roles to route selective, healthy mitochondria and effectively reduce mitochondrial diseases, this may be a great thing. Research has a target to fund. The rest are matters of hopes and prayers.

Scientific reason is questionably noble. Many experiments, however, are like quixotic battles with dragons in search of a holy grail. Mitochondria and 3-parent babies may or may not partner with positive conclusions. In successive generations, there may be more invasive dilemmas facing humanity than mitochondrial disease. Or mitochondrial disease may be more pervasive. Is it a roll of the dice? Either the fictional Frankenstein or the majestic hero awaits. Beyond dreams lie answers that we may not live to realize. There are other choices to control mitochondria diseases and we may want to deal with their moral implications before jumping into newer, possibly consequential technologies.

Heavy Metals and heart health

Do you enjoy heavy metals? Heavy Metal may be great music. Your body requires metals (minerals) in trace amounts for stable health. Too much may be hazardous to your health, even poisonous. Metal and heavy metal nutrients can bring life and death. They are vital to cellular maintenance. Too many metals may contribute to heart attacks, strokes, and cancers. Know how much metal you need to enjoy life?

Metals are very important to your body’s normal functioning. Iron, for example, is found in hemoglobin, a molecule in red blood cells that carries oxygen throughout your body. Iron is essential in tiny trace, An iron deficiency may lead to anemia, general fatigue, weakness. shortness of breath, and dizziness. Your body has many trace metals. Other metals your body requires are zinc, copper, manganese, selenium, chromium, and molybdenum. Many of these are included in most multiple vitamins. Some metals are often found in medicine formulas, such as aluminum, bismuth, gold, gallium, lithium, and silver. Then there are heavy metals like mercury, arsenic, and lead that are highly toxic to your body but essential for manufacturing products.

Exposure to heavy metals and their absorption into our body systems are often indirect and build-up is cumulative over time. Yet, most people don’t have an idea about the effects that even harmless metal exposure might have.

Very few realize that Calcium is a metal and also a vital nutrient for teeth and bones. It also is an active ingredient in common antacids sold in pharmacy and convenience stores. Some dairy products and dairy substitutes fortify additional calcium for marketing purposes. Accidental overdosing calcium is easy because of its availability. Calcium, over time, can contribute to the hardening of the arteries that may result in heart attacks and strokes. Even if your cholesterol is in the normal range!

Calcification can show up in breast tissue and, prior to crystallization, may not be detected by mammograms. Crystallized calcium may be the cause of many observed lumps in breasts. While most are not cancerous, calcium may (in certain conditions) be associated with forms of invasive cancer.

We have said that Iron is essential for health in trace amounts. Taking too much Iron in your diet can be lethal. Iron overdose has been one of the leading causes of death caused by toxicological agents in children younger than 6 years. While Iron in the bloodstream is vital for delivering oxygen to cells, overdose can kill cells. Large amounts of Iron is an extremely corrosive substance to the GI tract, and may induce abdominal pain, vomiting, and diarrhea.

Some heavy metals may be surreptitious and confusing. We are taught about how beneficial it is to eat fresh-water salmon and tuna fish. While there are many health benefits, seafood and fish store Mercury in their bodies, some more than others. In an average adult diet, Mercury levels may be harmless. Some fish and shellfish contain higher levels of mercury that may harm an unborn baby or young child’s developing nervous system. Five of the most commonly eaten fish that are low in mercury are shrimp, canned light tuna, salmon, pollock, and catfish, but, be advised, that eating more than 12 ounces of these low-mercury fish may be harmful in the long-run.

Mercury occurs naturally in the environment and can also be released into the air through industrial pollution. Mercury falls from the air and can accumulate in streams and oceans. Mercury transforms into methyl mercury in the water. Naturally, Fish absorb the methyl mercury as they feed in these waters and so it builds up in them. If young children are exposed to fish with high mercury levels, cerebral palsy, blindness and deafness may result. Methyl mercury damage is usually irreversible. Treatment is determined by the severity of the condition and is similar to that given for cerebral palsy.

According to the US Environmental Protection Agency, some forms of mercury may lead to muscle weakness, and mental disturbances. Mackerel, Shark, Swordfish, and Tilefish generally have the highest levels of mercury and are not recommended for pregnant women or young children. In its pure form, Mercury was once used in dental fillings and as an inactive base in some pills. What do they mean by inactive?

Supplements containing the metal Selenium make claims that it is beneficial at keeping thyroid levels in the normal range, among many other things. Most dietary Selenium comes from fish, grass-fed and pasture-raised meats, whole grains, and nuts.

The recommended dietary allowance of Selenium for adults is about 55 micrograms daily. It acts as a powerful antioxidant when combined with certain vitamins. Doses of over 200 micrograms daily may result in a form of diabetes. An overdose of selenium may cause bad breath, fever, nausea, and liver, kidney and heart problems. At high enough levels, selenium could possibly be a factor that results with death.

Think about lead poisoning, one of the more common toxic heavy metals. It was found in paint and gasoline up to the 1970’s. When homes are rented or sold, owners have to indicate a “lead notice” to prevent possible accidents from exposure to older paint layers. Sometimes toys imported from China may also have lead-based finishes. Accumulated exposure may be very harmful.

The signs and symptoms of lead poisoning in children may include: Developmental delay, Learning difficulties, Irritability, Loss of appetite, and Sluggishness and fatigue. There may also be abdominal issues.

There is one metal that your body really needs. It is called Magnesium for muscle, nerve, heart, ad bone health. Magnesium is needed for more than 300 biochemical reactions in the body. Prenatal magnesium deficiency has been inferred with autism and other early development disorders.

Excitability, Muscle weakness, and (excessive) Sleepiness have been associated with magnesium deficiencies. Getting your magnesium quota from foods is really easy. Most dietary magnesium comes from vegetables, such as dark green, leafy vegetables, legumes, whole-grain rice, nuts, and (some) soy products.

Though rare, magnesium overdose may lead to hypertension, vomiting, unintentional weight loss, slow breathing, kidney stress, and a possible calcium deficiency. While magnesium reportedly helps fight against accumulation of heavy metals in your body, further studies are needed.

There’s something wise about the health benefits of oysters. They are one of the foods that deliver the highest natural source of Zinc, another beneficial metal. For over 20 years, doctors claimed that Zinc can reduce colds from viruses.

Zinc has also been associated as beneficial to ADHD (attention deficit-hyperactivity disorder) and the development of Alzheimer’s Disease. Zinc may benefit skin and fertility. Sounds great, doesn’t it?

Taking too much Zinc may result in digestive problems and may lower your immunity system. Zinc competes with copper for absorption in the human body. Having an overdose of zinc unbalances your copper levels which become deficient. Taking too much Zinc may affect a change in taste and smell. Other Zinc side-effects may contribute to dizziness, chest pain, trouble breathing, fever, chills and jaundice, when taken at higher than recommended quantities.

Sometimes there can be too much of a good thing. Too much cake may make you fat. The acids in coffee may attack tooth enamel, for example. Too much milk brings healthy bones but possible circulatory problems. Certain seafood and fish may result in nerve disorders. It really is difficult. While heavy metals have benefits they may prematurely kiss you toward a stairway to heaven and a black Sabbath. Beware! Overdosing on heavy metals can impact the qualities of your life.

Heavy metals and metals may be nutritious and healthy in tiny amounts. Before dosing up or eating certain foods, especially when pregnant, their content in docile, everyday foods and supplements may be poisonous. Check with your doctor or nutritionist. The symptoms can be confusing but harmful if a possible associative suspicion is overlooked.

Many multivitamin supplements include metals as minerals. These small amounts help prevent deficiency but many of these come from healthy diets. How many people follow healthy diet guidelines? Sticking to that source will help you reap their benefits. It’s advisable not to over-supplement or you’ll reap consequences.

Careful review of heavy metals and metals in your diet may make the music of life more appealing.

Paralyzed Patients Move with Spinal Stimulation

The early 19th-century was fascinated with electricity. Dr. Frankenstein used electricity to restore life to a lifeless body. Many people suffer from paralysis, the inability to move limbs or bend the torso. Research into Neuro-electric impulses and spinal stimulation seem to help some patients regain movement.

Being paralyzed is among the biggest and most disabling nightmares. For many years, if paralyzed, you were bed-ridden or immobilized in wheelchairs. Of ambulatory disorders, the inability to control legs, arms, feet, neck, and other things, paralysis was among the worst. Whether it was due from disease, traumas, or bullets, being paralyzed was often perceived as death. For decades, it was near hopeless.

In an article in Brain (April 8), a study was published that show how 4 men, paralyzed for over two years, regained movement with the aid of implanted electro-stimulators in the spine. Patients could move by use of a remote control device. The research was covered by the National Institutes of Health. Subjects were paraplegic patients who lost sensation and movement in arms and legs.

The bioengineering institute at United States’ National Institutes of Health is funding research to develop noninvasive stimulators. That way, the electrical pulses can be delivered through the skin rather than requiring surgery to implant a device.

The unique clinical research approach was developed by V. Reggie Edgerton, Ph.D., a professor at the UCLA Department of Integrative Biology and Physiology. Edgerton is notably connected with the Christopher Reeve Foundation and the Michael J. Fox foundation.

Few people realize that in virtually most ways our body is an electric powerhouse. A normal, functioning body uses transduction to convert what we eat and think about into a complex living network. All living organisms are made of individual and identifiable cells, whose number, together with their size and type, ultimately defines the structure and functions of an organism. Cells are involved in helping to preserve and create energy in our bodies. Nerves and neurons behave like cells as well. When a disease or injury forms, the normal flow of energy is blocked.

In small cases, like burning your finger when touching hot cookware, the perceived pain sets off a response through releasing a set of chemicals called endorphins that reduce perceived pain.

People who suffer major injuries that sever nerve and cellular connections block the smooth flow of transductive actions. Many things can happen when this occurs. One of these may be paralysis of a region, large or small. The electrical energy flow is blocked.

In Asia, that electrical body energy is called Chi. Chi is the internal energy that circulates through the body, according to many eastern martial arts and medical traditions. These practitioners believe when chi is blocked, either through natural causes or more nefarious means, it can stop us from being able to function physically, mentally and emotionally for a small amount of time or permanently. Through various methods, the goal is to free the flow of natural chi.

A paralyzed limb may be blocked by various means. Through an understanding of the electrical impulses the body uses, a paralyzed limb may be activated by implanting an electrical pulse generator at the core of the blocked location. In many cases, based on our limited knowledge, it is somewhat speculative. In the NIH study, it worked with those 4 paralyzed men.

Of course the unblocking and reactivation of those neuromuscular areas are only the beginning. Physical therapy and/or prosthetics may be required to possibly help restore more full functioning.

What makes this study so interesting is how those pulses work to help mobilize what was thought to be immobile, virtually lifeless. Sometimes what is not known may just require the restimulation of the blocked chi.

It takes innovative approaches to help combat and treat disorders. Some of those are seen as ancient alternative methods.

Current medical education is pushing vast numbers of doctors and medical professionals that are paralyzed when it comes to what is perceived as new approaches to medical problems. Sometimes modern and accepted traditional methods do not work for those rare cases that are beyond average.

Fortunately, there are some thinkers that explore through the dark, curvy tunnels and come up with novel approaches. Long term results may be speculative. Having a light at the tunnel’s end is a remarkable thing at the very least.

One can’t surmise that all paralyzed people may one day move again, walk and dance. This research means there is hope. The fictional Dr. Frankenstein wasn’t all that wrong. He just wasn’t ready to understand that electricity can be therapeutic to those that have life. Seeming lifeless paralyzed patients may one day move with spinal stimulation. You are the body electric.