Alzheimer disease and neurostimulation pacemaker

The powers of cognition (the ability to recognize people, places, things and relationships) are believed to take place in the frontal lobe areas of the brain. Some theorists believe that when certain areas of the frontal lobe degrade, so do the rapid access to the entire brain’s cognitive networks. New research seems to be emerging on creating digital pacemakers to stimulate those tissues of the frontal cerebral cortex that otherwise might develop Alzheimer Disease.

Cognition is about thinking and interpreting sensory perceptions – touch, see, hear, smell, and taste. We create emotional attachments to these senses and the viability of those senses off significant contributions to survival and growth. These begin at birth. Some say before birth, as evolutionary genetic markers pass along to generations.

Many people get frightened when they seem forgetful or get stuck on that tip-of-tongue phenomenon. Some fear these are signs of Alzheimer Disease. Other causes for memory problems can include aging, medical conditions, emotional problems, mild cognitive impairment, or another type of dementia.

Alzheimer Disease was once exclusively attributed to aging. It is the degradation of the ability to develop and access cognitive networks. Simply put, it isn’t. Many adults maintain cognition throughout their entire lifespans. Alzheimer disease may also form at much earlier ages. Cognition is a very lively, experimented topic. The development of Alzheimer disease and cognitive research are part of a mutually cohesive network with many branches. Can brain stimulation of certain areas improve chances of reducing or avoiding the effects of Alzheimer disease?

The use and research of brain pacemakers is less than a decade old and was originally developed to help treat Parkinson’s disease. A significant research sponsor is Michael J. Fox, a popular TV actor who was diagnosed with Parkinson’s.

When it comes to Alzheimer Disease, there are many memory disorders. Currently research theorists on the development of Alzheimer disease debate inferences of causality.

The problem has been that as it emerged beyond the aged norm of senility, Alzheimer’s disease was diagnosed with complete accuracy only after death, when microscopic examination of the brain reveals the characteristic plaques and tangles. This leads to questions as to why so many living people are being diagnosed with Alzheimer disease?

There has been much evidence that has shown how mice kept in a stimulated environment (vs mice in a non-stimulated environment) developed more brain tissue and neuron networks. Neurologists have been discussing that physical exercise produces BDNF or Brain-derived neurotrophic factors. BDNF, it is believed, promotes the survival of nerve cells (neurons) by playing a role in the growth, maturation (differentiation), and maintenance of these cells. It may play a role in building new neuron networks. Some studies support that BDNF increases as a result of physical exercise, aiding neuronal health. The presence of BDNF acts as a natural stimulant for certain brain areas. Since BDNF is genetic, can the reduction or absence of BDNF be behind some cognitive declines?

Cardio-exercise, REM Sleep, Antioxidants found in Coffee or Tea and Meditation help produce BDNF. Subsequently, stress, sugar, and social isolation may reduce BDNF. As such, some that are immobile or old (lacking social networks) might be developing some cognitive impairment because of lower BDNF levels.

According to BBC News,Doctors have known for some time that loneliness is bad for the mind. It leads to mental health problems like depression, stress, anxiety, and a lack of confidence. But there’s growing evidence that social isolation is connected with an increased risk of physical ill health as well. Again, stimulation helps cognitive wellness.

Use of brain pacemakers to help prevent cognitive decline is relatively new and few agree where they should be implanted. Nonetheless, Nanobioelectronics represents a rapidly developing field with broad-ranging opportunities in fundamental biological sciences, biotechnology, and medicine. Instead of referring to these as pacemakers, I prefer neuroprosthetics for monitoring and treating neurological diseases that may help resolve some of those cognitive pathologies that we only are beginning to fathom. Be it Parkinson’s, dementia (there are 4 types of dementia), aphasia, or Alzheimer disease symptoms, there are futures to behold.

There are many things that disrupt access to memories. Finding the seat to how memories are retrieved, processed and accessed is very complex and often to broad to even consider. Normal memory function involves many parts of the brain. Any disease or injury that affects the brain can interfere with memory. Amnesia, for example, might result from a physical trauma from an injury or accident. It may also develop from other causes, often undefined. Dissociative amnesia is organic and may results from a medical or psychological cause as opposed to direct damage to the brain.

There are two types of amnesia:

Anteror Grade Amnesia – Anterograde amnesia is a loss of the ability to create new memories after the event that caused the amnesia, leading to a partial or complete inability to recall the recent past, while long-term memories from before the event remains intact. In a sense, one with Anteror Grade amnesia has no short-term memory.

RetroGrade is a loss of memory-access to events that occurred, or information that was learned, before an injury or the onset of a disease. … It is not to be confused with antero-grade amnesia, which deals with the inability to form new memories following the onset of an injury or disease. One with retrograde may create new memories.

While neuroscience has made inroads at understanding the locations of where memories are stored and, possible treating amnesia. Yet, as result of research, amnesia – particularly antero-grade amnesia – was medically induced. This happened in the case of H.M.

The high incidences of cognitive loss and Alzheimer disease continue despite vast experimentation and research. Are more people being diagnosed with Alzheimer’s than before. There is a genetic marker, APOe-4, that seems to cite some evidence. Yet there are clean genes, dirty genes, and mutated genes. And nutritionists believe that this gene could be influence by dietary factors.

But is APOe-4 the only gene behind Alzheimer onset? Is there more research necessary? In the complex universe of the brain, there is obviously a vast network of questions covering nutrition, neurotransmitters, neurotransmission co factors, and infinite variables from environment and activity.

How would positive results of an APOe-4 test and scale influence one’s life, career, and state of living?

Are we dealing with Alzheimer disease, micro-stroke with cognitive decline, or other cognitive issues?

Of course many of the research experiments aren’t well funded. Perhaps some corporate donors might want to sponsor the research. Elon Musk, of Tesla and Space-X, is developing Neuralink that connects brains with computers. While Neuralink shows no ambitions to treat Parkinson or Alzheimer disease, it may stimulate other business leaders to consider possible investments.

I supported and studied frontal lobe dementia. Frontal lobe dementia does not cause memory loss, but it can exhibit cognitive and neurological problems similar to those caused by Alzheimer’s disease or stroke. The particular area of atrophy is not dissimilar between schizophrenia and dementia. Similar theorists believe that long-term memory storage may have been disaffected due to biochemical deficiencies in REM sleep. On either level, there are no clear etiologies that indicate or predetermine any causal effect of alzheimer disease type symptoms. Yet schizophrenic symptoms and dementia symptoms share some similarities that may be from a missing link between the cortex and the mid-brain memiry centers.

Genetics, diet, smoking, alcohol, substance abuse might be not highly associative to dementia. The problems involve neurotransmitters, catalysts, inhibitors, proteins, peptides, enzymes and a host of variability make us wonder ever more how this prefrontal lesion originated and its effects on memory and organized thinking.

A neurostimulation implant pacemaker therapy may be one significant approach to help suppress cognitive deficits. Using nano-electronic intervention for cognitive decline and avoiding Alzheimer disease, is a promising exploration into helping patients and families deal with cognitive decline. Whether a brain pacemaker will be a benefit is really up to further research as to where they could best stimulate possible reduction in Alzheimer disease decline. Yet, the pot of gold at the end of the rainbow may still require a series of quixotic games, puzzles, and questions to conclusively answer. We still don’t know what lies ahead. Do you?

Halal ketogenic kosher vegan dieting

Everyone, at one time or another, thinks about dieting.There are so many diets to choose from. There are at least 38 different diets that deem some worthiness. There are actually hundreds of dietary methods. Dieting and choosing a diet often seems punitive and often require lifestyle discipline. For most, the menu is confusing. For many, it has been coded by deities. Is one better than the other?

There are many faiths and religions covering billions of people that faithfully follow divine diets. People seem to follow diets based on godliness than health and wellness. Are they healthy in today’s times? Were they ever designed for the healthy lifestyles we seek?

Indeed, virtually all diets require enduring faith. For many people, religions have established blueprints with no second-guessing. But do those diets deliver health benefits or were they designed to counter pantheist and pagan cultures that lived concurrently? Diets often tend to fail but, with help of gods, faith is often more esteemed than will.

Diet is considered a four-letter word. Diet isn’t one of those words .For many people in western civilization, to follow a diet as a healthy lifestyle, is considered a torrid road to Inferno. Historically, dietary lifestyles were bound by divinity, evolution of tools (i.e. veganism), and science (i.e. ketogenic). The latter trail behind lifestyle followers of those that have divine origins. We will be discussing Islamic Halal, Jewish Kosher, Garden of Eden’s Vegan, and scientific Ketogenic.

Over 1-1/2 billion people follow halal and kosher dietary rules that have come from divine origin. There are also special dietary laws for Buddhism, and Hinduism. Christianity did not develop elaborate dietary rules and customs. This probably grew out of the controversy between the Judaic and Greek Christians and the Roman church during the earliest years of Christianity. It is believed that Jesus and Mary followed kosher laws and vegetarian diets.

When it comes to ritually slaughtering meat and the prohibition of pig meat, halal and kosher follow very specific and similar laws. Halal adheres to Islamic law, as defined in the Quranran. Virtually all vegetarian cuisine is halal if it does not contain alcohol. The most common example of non-halal (or haram) food is pork (pig meat products). While pork is the only meat that categorically may not be consumed by Muslims (the Quran forbids it Sura 16:115), other foods not in a state of purity are also considered haram (not halal).

Kosher follows specific laws throughout several passages of the Torah or Five Books of Moses.. A kosher species must be slaughtered by a Shochet, a ritual slaughterer. Since Jewish Law prohibits causing any pain to animals, the slaughtering has to be effected in such a way that unconsciousness is instantaneous and death occurs almost instantaneously. In kusher, animals must chew their cud and have a split hoof. Poultry (birds) and fish also have specific rules. All ritually slaughtered must not be from a predator species. In addition, meat and milk must not be consumed together.

The key elements are that health is not subscribed to either halal or kosher, other than the animal must be a healthy one. These rules are found in the scriptures of divine origins. That means fat and cholesterol issues of today, were not included. Nor were mortality statistics or current diseases.

Yet, most Jews and Islamic people have followed these rules for thousands of years, without question. These have been deeply integrated into their lifestyles through setting up homes and abstaining from certain foods. means abstaining from the use of alcohol (Islam) and pork or from things which contain the by-products of those. This accounts to over 1-1/2 billion people following the precepts set a long time ago through divine scriptures.

The divine scriptures have also places a focus on the vegan diet. It begins at the creation of the world. “And to every beast of the earth, and to every bird of the air, and to everything that creeps on the earth, everything that has the breath of life, I have given every green plant for food.” —Genesis 1:30. It was really afterwards that the Lord starting granting compromises about meat. Vegans, as individuals, usually don’t think about the Genesis quote but following a vegan diet does require some religious fervor.

Vegans have many different motives for choosing an all vegetable, fruit, and grain diet. For those seeking weight loss, some vegans actually gain weight. There is considerable debate whether being vegan is healthy or not. A good vegan diet is still based on calories, nutrition, and activity. Unlike Halal and Kosher, according to the Academy of Nutrition and Dietetics, vegans are less likely to develop heart disease, cancer, diabetes, or high blood pressure than meat-eaters are.

Many vegan wannabes make a mistake about vegetarianism and veganism. Like kosher or halal being a vegan follows a strict type of vegetarianism that excludes meat and all animal products. Vegans do not eat meat, fish, eggs, dairy products, or any foods containing them. A vegan diet relies on plant-based foods including fruits, vegetables, grains, beans, nuts, and seeds. Seeds, as in nuts, are great sources of dietary fats, protein, nutrients that include magnesium. Like kosher and halal, vegans don’t necessarily mimic other non-vegan foods, they create many of their own. Yes, dark chocolate is vegan!

While considered healthy, the Vegan Coach does suggest that vegans choosing weight loss as a goal simple carbs (such as white rice or white pasta) and instead reach for whole grains (like brown rice or whole grain pasta) for lasting energy and to encourage weight loss. DO cut back on your sugar intake. Sugar is bad news and the more you eat the harder it will be to lose weight.

The Vegan Coach notes that some vegans tend to get fat and that is due to consumption of excess carbohydrates (sugars and starches). Everything (other than most dairy, all meat, poultry, and fish) naturally contain carbohydrates. Vegetables, fruits and, especially, grains. Basically all core foods vegan eat. That isn’t necessarily bad.

The Dietary Guidelines for Americans recommends that carbohydrates make up 45 to 65 percent of your total daily calories. So, if you get 2,000 calories a day, between 900 and 1,300 calories should be from carbohydrates. That translates to between 225 and 325 grams of carbohydrates a day. Primary foods with the highest carbohydrates are:
Fruit. Whole fruit and fruit juice.
Grains. Bread, pasta, rice, quinoa, oats, wheat, crackers, and cereal.
Legumes. Beans and other plant-based proteins.
Starchy Vegetables. Potatoes and corn.
Sugar – Processed or Raw table sugar as sucrose, glucose, fructose, lactose, and maltose.

Excess carbohydrates convert to body fat as storage. If you exceed your calories from carbohydrates, and don’t move, you gain weight over time. Even as a vegan.

Adopting a ketogenic lifestyle turns the vegan diet backwards. Meat, dairy, fish, poultry are staples. Few vegetables, fruits, and grains are consumed. Depriving your body of carbohydrates will be naturally compensated by your body AFTER it uses natural fat storage.

Ketogenic is more of a science based diet that originally was used to curb epilepsy symptoms. The side effect was weight loss and long-term management. Like kosher, halal, and (somewhat) vegan, ketogenic is a lifestyle that doesn’t have any ties to divine commandments. A ketogenic diet is a personal choice and, like vegan, kosher, and halal, must be followed as a lifestyle.

While there are many variables in low-carbohydrate dieting, ketogenic diets work best when you place your body in ketosis. Ketosis is a normal metabolic process. When the body does not have enough glucose for energy, it burns stored fats instead; this results in a build-up of acids called ketones within the body. Some people encourage ketosis by following a diet called the ketogenic or low-carbohydrate diet.

What happens when stored fats are used? The liver, kidney, and brain produce just enough of natural body energy sources called ketones that keep your body functioning. Getting your body to do this means reaching consistent ketosis. the daily intake of net carbs required to enter ketosis could vary from 20 to 100 grams per day. Most people, who have experienced ketosis, claim to have reached that state at about 20-50 grams of net carbs per day. It varies per person. 50 grams is equivalent to a cup of coffee with milk and 2 spoons of sugar OR 1 bagel dry.

A net-carbohydrate is calculated by subtracting the food’s fiber content from the total carbohydrates. Suppose you have a can of beans (that strangely yields about 3 servings). Each serving has 20 grams total carbohydrates. There are 8 grams of fiber per serving. The net-carb (total minus fiber) is 12 grams per serving. One of the popular low-carb diet strategies, Atkins Diet, conjured up this net-carb formula. This way you might enjoy bread while following your ketogenic goals.

Typically, a slice of whole-wheat bread has 20 grams total minus 5 grams of fiber, to deliver 30 grams net carbs per 2 slice sandwich. Low-carb bread alternatives might be some wrap-like pita or flat breads, delivering a 1-bread sandwich. A low-carb bread might have a 10 gram total, 5 gram fiber, yielding a 5 gram net carb. Net-carb is a neat trick to help you enjoy a sandwich.

Adopting a ketogenic diet means a long-term lifestyle choice. While not divinely commanded, the ketogenic diet lifestyle helps keep you trim and helps reduce weight at a recommended level in order to avoid weight related diseases, such as diabetes, chronic obesity, arthritis, and others. Some say that a combination of ketosis and exercise might even help memory by stimulating a certain neurotrophic factor in your mid brain.

Since its discovery almost about 30 years ago, neuroscientists and neurologists have studied that the secreted neurotrophin brain-derived neurotrophic factor (BDNF) has been firmly implicated in the differentiation and survival of neurons of the central nervous system. The BDNF role has also been emerging as an important regulator of synaptogenesis and synaptic plasticity mechanisms underlying learning and memory in the adult central nervous system. A ketogenic diet and moderate exercise has demonstrated strong links with BDNF production in the hippocampus region of the brain. The hippocampus is associated mainly with memory, in particular long-term memory.

There is much to be said about those diets long foretold through the Old Testament and the Koran. They illustrate respect and cleanliness of animals and other foods. This respect may allow for an above average mortality rate than others not following kosher or halal rules.

According to a recent book, Jesus and Mary were kosher abiding vegetarians (not totally vegan). This lifestyle also extended to the original Aramaic Christians that lived within adjacent environments. Devout Jews and Islamic follow kosher and halal as strict dietary laws. Food is an important part of religious observance for many different faiths, including Christianity, Judaism, Islam, Hinduism and Buddhism. Health-wise, those laws, customs and guidelines are more faith than science.

The ketogenic diet has been academically and scientifically examined for nearly 100 years. Ketogenic results are based on studies ranging from diet, metabolism, and a wide range of sciences. While low-carb ketogenic lifestyles have grown in popularity over the past 30 years (as opposed to thousands), many nutritionists cite science studies that suggest that the ketogenic lifestyle may be attributed to healthy longevity. The ketogenic adoption to fat and protein over natural fruits and vegetables appear to astonish and irritate old ideas.

Apart from religious lifestyle diets, there are hundreds of dietary lifestyles competing to be top-of-the-list. Dieting or maintaining good dietary health by choice is more of a failing game of thrones. According to the New York Times (1999) “95% Regain Lost Weight. Or Do They? It is a depressing article of faith among the overweight and those who treat them that 95 percent of people who lose weight regain it — and sometimes more — within a few months or years”. Psychology Today claims, given many human instincts and habits, this dietary struggle is so constant that dieting isn’t worth it.

For religions, devout followers adopt dietary laws as integrated through many generations. Vegans might have a couple generations but usually volunteer to the lifestyle for varied reasons. Ketogenic dieting is difficult, especially within a world that heavily markets carbohydrate-rich foods. It’s rules are simple but adoption takes endurance for months through years. Once ketosis is disrupted, you become a carb animal again.

While a ketogenic diet may reduce cholesterol and blood sugar levels, improve memory, calm bi-polar symptoms and episodic epilepsy, the big obstacle is adopting a ketogenic lifestyle as a habit – with minor changes as you reach your goals.

The wrath of gods may not smite you for disobeying dietary laws. At least for this life, ketogenic dieting offers many positives if you faithfully follow it. The ketogenic diet is a low-carb, high-fat diet that theoretically lowers blood sugar and insulin levels (in normal individuals). Ketosis shifts the body’s metabolism away from carbs and towards fat, protein, and ketone production. As you reach targeted weight goals, you may add carbohydrates when exercising.

HealthLine lists four of several variations of ketogenic dietary modes:

Standard ketogenic diet (SKD): This is a very low-carb, moderate-protein and high-fat diet. It typically contains 75% fat, 20% protein and only 5% carbs (1).

Cyclical ketogenic diet (CKD): This diet involves periods of higher-carb refeeds, such as 5 ketogenic days followed by 2 high-carb days.

Targeted ketogenic diet (TKD): This diet allows you to add carbs around workouts.

High-protein ketogenic diet: This is similar to a standard ketogenic diet, but includes more protein. The ratio is often 60% fat, 35% protein and 5% carbs.

I employ a different one that stays away from saturated fats and focuses more on mono- and poly-unsaturated fats. It’s a more difficult variation that relies mostly on nuts, soy, wheat gluten, and fish. Works for me but I don’t recommend this for most.

There are differences when we discuss low-carb and ketogenic. Low-carb can be any reduction of carbohydrates. Ketogenic means limiting your carbohydrates to 40 to 60 grams per day. Some say 20 grams is better. I’d say anything averaging below 60 grams per day will ignite the liver and brain to create ketones for weight loss and energy.

I may believe in god but humans have to find their way toward healthier, happier and longer lives. There’s an often debated phrase that God helps those that help themselves. The low-carb ketogenic approach might seem to work fast in helping to drop inches. Yet, like kosher, halal, and veganism, ketogenic requires a long, religious effort to make those choices that reap healthy dietary rewards.

BDNF BDSM bring healthy heart brain memory

A few years ago, the bestselling 50 Shades of Grey novels unleashed the acceptance of healthy foreplay (using light BDSM) in the bedroom or elsewhere. AARP and other online sources indicated that active foreplay calorie use and improved heart rate, anecdotal from use of a fit-bit.

BDNF(Brain-derived neurotrophic factor) are processes that are are a family of biomolecules – nearly all of which are peptides or small proteins – that support the growth, survival, and differentiation of both developing and mature neurons. Within the brain, BDNF is released by either a nerve cell and binds to a receptor on a nearby nerve cell. The associative process prompts the increased production of proteins associated with nerve cell survival and function. Basically, BDNF is an active neurotrophin that helps build cognition and memory. BDNF production is one theory that helps prevent onset of Alzheimer’s. Is it fully automatic?

According to neurologist and author Dr. David Perlmutter, activity and a ketogenic-type diet may help initiate BDNF activity to improve brain health longevity.

BDNF is like a neuron growth hormone. As a normal progression of aging, many hormone production levels decrease. Studies are exploring the possible roles reduced BDNF might have with developing memory decline. The study’s conclusion was a little unclear of what lifestyle changes might need changing if BDNF regulation is, indeed, a factor of Alzheimer’s Disease development.

Dr. Perlmutter believes that low-carbohydrate diets, in addition to aid BDNF constancy also may reduce body inflammation that might influence heart and brain health. Perlmutter further breaks down what carbohydrates are better than those you’re eating now.

It’s a shared belief between Perlmutter and other neurologists that walking, running, or any aerobic exercise helps release BDNF that helps develop synaptic growth in the mid-brain. The area is the hippocampus that is often associated with moods and memory. One existential psychology theorist had a pretty cute explanation about this area. He believed the hippocampus was a picture book of our memories – what we like or dislike.

Of course, discussing routine, lifestyle dieting and doing it are two different realities.

Of course, one possible way to boost memory is coffee. We love our coffee. The caveat is no sugar or milk. The key ingredient is caffeine. Johns Hopkins study showed that caffeine helped retain long-term memory. There was no correlation whether BDNF was part of the coffee test results. Coffee, as the most consumed beverage, also has been studied to show other benefits.

Doctors and theorists seem to agree that modified ketogenic diets coupled with exercise or any consistent aerobic activity offer many healthy benefits. The BDNF hypothesis is helped along by ketogenic dieting and activity offering a package of body and brain benefits.

Consensual, intimate BDSM (dominant/submissive) might be a physical, calorie burning activity that might promote a good heart rate and possible BDNF through creativity and challenges. It is not deemed normal by many. It’s kinky. Yet it evokes much interest.

In BDSM alternative lifestyle role-play, the leader demands obedience from the following partner. Done well, the challenges might really tax thinking and BDNF production. Role-play is an activity and can be challenging and fun. It does require healthy communication in the game. Using BDSM as foreplay (along with a diet) might be an alternative to walking rapidly for 45-minutes. Even Italian researchers associate sexiness with BDNF. The thorough research was admittedly from a small sample of subjects. For BDNF, that’s amore.

Health also evokes much interest and the thousands of bestselling books (i.e. David Perlmutter’s Grain Brain book), response to content often resounds with a giant thud.

That may be due to the sugar that has been added to package foods is like a deadly drug and artificial sweeteners that we love and can’t change our addiction with. We are slaves of sugar! We are the subjects of a planned system that sugars are good. It is difficult to disobey. Any alternative is an acquired taste or seen as punishment.

Then there are the 0 calorie artificial sweeteners!!

Still want to sweeten your coffee?

In light of longevity, or general health, the potential benefits of leaner bodies and robust memories face insurmountable challenges from the lifestyles we’ve adopted. Modifying those perceptions are akin to being a masochist – and as socially inappropriate. Yet it takes little work if motivated.

Recently, several BDNF testing procedures have begun. There are also studies of BDNF saliva tests. BDNF neuroscience and cognitive researchers, over the past few years, have not accurately assessed quantities and qualities required to assure BDNF optimal ranges for possible memory retention and reduction of dementia symptoms. Neurologists, however, agree that ketogenic diets and aerobic physical activity together stimulate BDNF production in the brain.

If someone proved that BDNF was really a great way to preserve memory, would you follow a ketogenic diet and exercise?